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General Information
| Manuscript title | Role of phosphate in the central metabolism of two lactic acid bacteria - a comparative systems biology approach. |
| PubMed ID | 22325620 |
| Journal | FEBS Journal |
| Year | 2012 |
| Authors | Jennifer Levering, Mark W. J. M. Musters, Martijn Bekker, Domenico Bellomo, Tomas Fiedler, Willem M. de Vos, Jeroen Hugenholtz, Bernd Kreikemeyer, Ursula Kummer and Bas Teusink |
| Affiliations | Department of Modeling of Biological Processes, COS Heidelberg ⁄ BIOQUANT, University of Heidelberg, Germany |
| Keywords | Lactococcus lactis, metabolism of glucose, NMR, in vivo |
| Full text article |
Levering_2012.pdf
|
| Project name | not specified |
| Data used for | Model building and Model validation |
Model Information
| Model name | glycolysis Lactococcus lactis | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Organism | Lactococcus lactis | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Model type | ordinary differential equations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Category | Metabolism | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Number of reactions | 11 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Number of species | 11 + 4 co-metabolites | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Number of regulators | 3 activations + 5 inhibitions | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Number of parameters | 66 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Number of compartments | 2 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Dilution rate (h-1) | — | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Model file(s) and history |
LATEST levering1.xml
(2014-03-10 11:18:15 UTC
by Administrator KiMoSys
)
Preview
Preview file levering1.xml<?xml version='1.0' encoding='UTF-8'?>
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<times/>
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<divide/>
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<power/>
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<plus/>
<apply>
<power/>
<ci> Km_trioseP </ci>
<ci> n </ci>
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<ci> n </ci>
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</apply>
</apply>
<ci> Vmax </ci>
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<power/>
<apply>
<divide/>
<ci> pyruvate </ci>
<ci> Km_pyruvate </ci>
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<power/>
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<divide/>
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<apply>
<divide/>
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<times/>
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<plus/>
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<ci> Km_pyruvate </ci>
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<divide/>
<ci> NADH </ci>
<ci> Km_NADH </ci>
</apply>
<cn> 2 </cn>
</apply>
</apply>
<apply>
<plus/>
<cn> 1 </cn>
<apply>
<divide/>
<ci> ADP </ci>
<ci> Km_ADP </ci>
</apply>
</apply>
<apply>
<plus/>
<cn> 1 </cn>
<apply>
<divide/>
<ci> Pi </ci>
<ci> Km_Pi </ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn> 1 </cn>
<apply>
<divide/>
<ci> mixedacid </ci>
<ci> Km_mixedacid </ci>
</apply>
<apply>
<power/>
<apply>
<divide/>
<ci> mixedacid </ci>
<ci> Km_mixedacid </ci>
</apply>
<cn> 2 </cn>
</apply>
</apply>
<apply>
<plus/>
<cn> 1 </cn>
<apply>
<divide/>
<ci> NAD </ci>
<ci> Km_NAD </ci>
</apply>
<apply>
<power/>
<apply>
<divide/>
<ci> NAD </ci>
<ci> Km_NAD </ci>
</apply>
<cn> 2 </cn>
</apply>
</apply>
<apply>
<plus/>
<cn> 1 </cn>
<apply>
<divide/>
<ci> ATP </ci>
<ci> Km_ATP </ci>
</apply>
</apply>
</apply>
</apply>
<cn> 1 </cn>
</apply>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id='function_9' name='CK 2S 2P (1 double) 1Mm irr mod'>
<math xmlns='http://www.w3.org/1998/Math/MathML'>
<lambda>
<bvar>
<ci> Ki </ci>
</bvar>
<bvar>
<ci> I </ci>
</bvar>
<bvar>
<ci> Vmax </ci>
</bvar>
<bvar>
<ci> S1 </ci>
</bvar>
<bvar>
<ci> KmS1 </ci>
</bvar>
<bvar>
<ci> S2 </ci>
</bvar>
<bvar>
<ci> KmS2 </ci>
</bvar>
<bvar>
<ci> P1 </ci>
</bvar>
<bvar>
<ci> KmP1 </ci>
</bvar>
<bvar>
<ci> P2 </ci>
</bvar>
<bvar>
<ci> KmP2 </ci>
</bvar>
<bvar>
<ci> P3 </ci>
</bvar>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci> Ki </ci>
<apply>
<plus/>
<ci> Ki </ci>
<ci> I </ci>
</apply>
</apply>
<ci> Vmax </ci>
<apply>
<divide/>
<ci> S1 </ci>
<ci> KmS1 </ci>
</apply>
<apply>
<divide/>
<ci> S2 </ci>
<ci> KmS2 </ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<plus/>
<cn> 1 </cn>
<apply>
<divide/>
<ci> S1 </ci>
<ci> KmS1 </ci>
</apply>
</apply>
<apply>
<plus/>
<cn> 1 </cn>
<apply>
<divide/>
<ci> S2 </ci>
<ci> KmS2 </ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn> 1 </cn>
<apply>
<divide/>
<ci> P1 </ci>
<ci> KmP1 </ci>
</apply>
</apply>
<apply>
<plus/>
<cn> 1 </cn>
<apply>
<divide/>
<ci> P2 </ci>
<ci> KmP2 </ci>
</apply>
<apply>
<power/>
<apply>
<divide/>
<ci> P3 </ci>
<ci> KmP2 </ci>
</apply>
<cn> 2 </cn>
</apply>
</apply>
</apply>
</apply>
<cn> 1 </cn>
</apply>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id='function_2' metaid='COPASI34' name='CK 1S 2P (double) mod FBA'>
<annotation>
<COPASI xmlns='http://www.copasi.org/static/sbml'>
<rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'>
<rdf:Description rdf:about='#COPASI34'>
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2011-08-30T17:42:39Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<math xmlns='http://www.w3.org/1998/Math/MathML'>
<lambda>
<bvar>
<ci> Vmax </ci>
</bvar>
<bvar>
<ci> S1 </ci>
</bvar>
<bvar>
<ci> KmS1 </ci>
</bvar>
<bvar>
<ci> Keq </ci>
</bvar>
<bvar>
<ci> KmP1 </ci>
</bvar>
<bvar>
<ci> P1 </ci>
</bvar>
<bvar>
<ci> P2 </ci>
</bvar>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<ci> Vmax </ci>
<apply>
<divide/>
<ci> S1 </ci>
<ci> KmS1 </ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> Vmax </ci>
<ci> Keq </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> KmP1 </ci>
<ci> KmP1 </ci>
</apply>
<ci> KmS1 </ci>
</apply>
<apply>
<divide/>
<ci> P1 </ci>
<ci> KmP1 </ci>
</apply>
<apply>
<divide/>
<ci> P2 </ci>
<ci> KmP1 </ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn> 1 </cn>
<apply>
<divide/>
<ci> S1 </ci>
<ci> KmS1 </ci>
</apply>
<apply>
<divide/>
<ci> P1 </ci>
<ci> KmP1 </ci>
</apply>
<apply>
<power/>
<apply>
<divide/>
<ci> P1 </ci>
<ci> KmP1 </ci>
</apply>
<cn> 2 </cn>
</apply>
</apply>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id='function_4' metaid='COPASI35' name='CK 3S 2P mod GAPDH'>
<annotation>
<COPASI xmlns='http://www.copasi.org/static/sbml'>
<rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'>
<rdf:Description rdf:about='#COPASI35'>
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2011-08-30T17:43:49Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<math xmlns='http://www.w3.org/1998/Math/MathML'>
<lambda>
<bvar>
<ci> Vmax </ci>
</bvar>
<bvar>
<ci> S1 </ci>
</bvar>
<bvar>
<ci> KmS1 </ci>
</bvar>
<bvar>
<ci> S2 </ci>
</bvar>
<bvar>
<ci> KmS2 </ci>
</bvar>
<bvar>
<ci> S3 </ci>
</bvar>
<bvar>
<ci> KmS3 </ci>
</bvar>
<bvar>
<ci> Keq </ci>
</bvar>
<bvar>
<ci> KmP1 </ci>
</bvar>
<bvar>
<ci> KmP2 </ci>
</bvar>
<bvar>
<ci> P1 </ci>
</bvar>
<bvar>
<ci> P2 </ci>
</bvar>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<ci> Vmax </ci>
<apply>
<divide/>
<ci> S1 </ci>
<ci> KmS1 </ci>
</apply>
<apply>
<divide/>
<ci> S2 </ci>
<ci> KmS2 </ci>
</apply>
<apply>
<divide/>
<ci> S3 </ci>
<ci> KmS3 </ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> Vmax </ci>
<ci> Keq </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> KmP1 </ci>
<ci> KmP2 </ci>
</apply>
<apply>
<times/>
<ci> KmS1 </ci>
<ci> KmS2 </ci>
<ci> KmS3 </ci>
</apply>
</apply>
<apply>
<divide/>
<ci> P1 </ci>
<ci> KmP1 </ci>
</apply>
<apply>
<divide/>
<ci> P2 </ci>
<ci> KmP2 </ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<plus/>
<cn> 1 </cn>
<apply>
<divide/>
<ci> S1 </ci>
<ci> KmS1 </ci>
</apply>
</apply>
<apply>
<plus/>
<cn> 1 </cn>
<apply>
<divide/>
<ci> S2 </ci>
<ci> KmS2 </ci>
</apply>
</apply>
<apply>
<plus/>
<cn> 1 </cn>
<apply>
<divide/>
<ci> S3 </ci>
<ci> KmS3 </ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn> 1 </cn>
<apply>
<divide/>
<ci> P1 </ci>
<ci> KmP1 </ci>
</apply>
</apply>
<apply>
<plus/>
<cn> 1 </cn>
<apply>
<divide/>
<ci> P2 </ci>
<ci> KmP2 </ci>
</apply>
</apply>
</apply>
</apply>
<cn> 1 </cn>
</apply>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id='function_5' metaid='COPASI36' name='CK 2S 2P mod ENO'>
<annotation>
<COPASI xmlns='http://www.copasi.org/static/sbml'>
<rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'>
<rdf:Description rdf:about='#COPASI36'>
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2011-08-30T17:44:58Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<math xmlns='http://www.w3.org/1998/Math/MathML'>
<lambda>
<bvar>
<ci> Vmax </ci>
</bvar>
<bvar>
<ci> S1 </ci>
</bvar>
<bvar>
<ci> KmS1 </ci>
</bvar>
<bvar>
<ci> S2 </ci>
</bvar>
<bvar>
<ci> KmS2 </ci>
</bvar>
<bvar>
<ci> Keq </ci>
</bvar>
<bvar>
<ci> KmP1 </ci>
</bvar>
<bvar>
<ci> KmP2 </ci>
</bvar>
<bvar>
<ci> P1 </ci>
</bvar>
<bvar>
<ci> P2 </ci>
</bvar>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<ci> Vmax </ci>
<apply>
<divide/>
<ci> S1 </ci>
<ci> KmS1 </ci>
</apply>
<apply>
<divide/>
<ci> S2 </ci>
<ci> KmS2 </ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> Vmax </ci>
<ci> Keq </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> KmP1 </ci>
<ci> KmP2 </ci>
</apply>
<apply>
<times/>
<ci> KmS1 </ci>
<ci> KmS2 </ci>
</apply>
</apply>
<apply>
<divide/>
<ci> P1 </ci>
<ci> KmP1 </ci>
</apply>
<apply>
<divide/>
<ci> P2 </ci>
<ci> KmP2 </ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<plus/>
<cn> 1 </cn>
<apply>
<divide/>
<ci> S1 </ci>
<ci> KmS1 </ci>
</apply>
</apply>
<apply>
<plus/>
<cn> 1 </cn>
<apply>
<divide/>
<ci> S2 </ci>
<ci> KmS2 </ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn> 1 </cn>
<apply>
<divide/>
<ci> P1 </ci>
<ci> KmP1 </ci>
</apply>
</apply>
<apply>
<plus/>
<cn> 1 </cn>
<apply>
<divide/>
<ci> P2 </ci>
<ci> KmP2 </ci>
</apply>
</apply>
</apply>
</apply>
<cn> 1 </cn>
</apply>
</apply>
</lambda>
</math>
</functionDefinition>
</listOfFunctionDefinitions>
<listOfUnitDefinitions>
<unitDefinition id='substance' name='substance'>
<listOfUnits>
<unit kind='mole' scale='-3'/>
</listOfUnits>
</unitDefinition>
</listOfUnitDefinitions>
<listOfCompartments>
<compartment id='compartment_1' name='Intracellular' size='0.01'/>
<compartment id='compartment_2' name='Extracellular' size='1'/>
</listOfCompartments>
<listOfSpecies>
<species compartment='compartment_1' id='species_1' initialConcentration='0' metaid='COPASI2' name='G6P'>
<annotation>
<COPASI xmlns='http://www.copasi.org/static/sbml'>
<rdf:RDF xmlns:CopasiMT='http://www.copasi.org/RDF/MiriamTerms#' xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'>
<rdf:Description rdf:about='#COPASI2'>
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2011-11-08T14:09:23Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
<CopasiMT:is rdf:resource='urn:miriam:obo.chebi:15946'/>
<CopasiMT:is rdf:resource='urn:miriam:obo.chebi:21008'/>
</rdf:Description>
</rdf:RDF>
</COPASI>
<rdf:RDF xmlns:bqbiol='http://biomodels.net/biology-qualifiers/' xmlns:bqmodel='http://biomodels.net/model-qualifiers/' xmlns:dc='http://purl.org/dc/elements/1.1/' xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#' xmlns:vCard='http://www.w3.org/2001/vcard-rdf/3.0#'>
<rdf:Description rdf:about='#COPASI2'>
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource='urn:miriam:obo.chebi:21008'/>
</rdf:Bag>
</bqbiol:is>
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource='urn:miriam:obo.chebi:15946'/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</species>
<species compartment='compartment_1' id='species_2' initialConcentration='4.96534865142448e-06' metaid='COPASI3' name='FBP'>
<annotation>
<COPASI xmlns='http://www.copasi.org/static/sbml'>
<rdf:RDF xmlns:CopasiMT='http://www.copasi.org/RDF/MiriamTerms#' xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'>
<rdf:Description rdf:about='#COPASI3'>
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2011-11-08T14:09:45Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
<CopasiMT:is rdf:resource='urn:miriam:obo.chebi:28013'/>
</rdf:Description>
</rdf:RDF>
</COPASI>
<rdf:RDF xmlns:bqbiol='http://biomodels.net/biology-qualifiers/' xmlns:bqmodel='http://biomodels.net/model-qualifiers/' xmlns:dc='http://purl.org/dc/elements/1.1/' xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#' xmlns:vCard='http://www.w3.org/2001/vcard-rdf/3.0#'>
<rdf:Description rdf:about='#COPASI3'>
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource='urn:miriam:obo.chebi:28013'/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</species>
<species compartment='compartment_1' id='species_3' initialConcentration='0' metaid='COPASI4' name='triose-P'>
<annotation>
<COPASI xmlns='http://www.copasi.org/static/sbml'>
<rdf:RDF xmlns:CopasiMT='http://www.copasi.org/RDF/MiriamTerms#' xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'>
<rdf:Description rdf:about='#COPASI4'>
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2011-11-08T14:07:57Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
<CopasiMT:is rdf:resource='urn:miriam:obo.chebi:16108'/>
<CopasiMT:is rdf:resource='urn:miriam:obo.chebi:29052'/>
</rdf:Description>
</rdf:RDF>
</COPASI>
<rdf:RDF xmlns:bqbiol='http://biomodels.net/biology-qualifiers/' xmlns:bqmodel='http://biomodels.net/model-qualifiers/' xmlns:dc='http://purl.org/dc/elements/1.1/' xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#' xmlns:vCard='http://www.w3.org/2001/vcard-rdf/3.0#'>
<rdf:Description rdf:about='#COPASI4'>
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource='urn:miriam:obo.chebi:29052'/>
</rdf:Bag>
</bqbiol:is>
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource='urn:miriam:obo.chebi:16108'/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</species>
<species compartment='compartment_1' id='species_4' initialConcentration='0' metaid='COPASI5' name='BPG'>
<annotation>
<COPASI xmlns='http://www.copasi.org/static/sbml'>
<rdf:RDF xmlns:CopasiMT='http://www.copasi.org/RDF/MiriamTerms#' xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'>
<rdf:Description rdf:about='#COPASI5'>
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2011-11-08T14:09:56Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
<CopasiMT:is rdf:resource='urn:miriam:obo.chebi:16001'/>
</rdf:Description>
</rdf:RDF>
</COPASI>
<rdf:RDF xmlns:bqbiol='http://biomodels.net/biology-qualifiers/' xmlns:bqmodel='http://biomodels.net/model-qualifiers/' xmlns:dc='http://purl.org/dc/elements/1.1/' xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#' xmlns:vCard='http://www.w3.org/2001/vcard-rdf/3.0#'>
<rdf:Description rdf:about='#COPASI5'>
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource='urn:miriam:obo.chebi:16001'/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</species>
<species compartment='compartment_1' id='species_5' initialConcentration='0.00177296284823029' metaid='COPASI6' name='PEP pool'>
<annotation>
<COPASI xmlns='http://www.copasi.org/static/sbml'>
<rdf:RDF xmlns:CopasiMT='http://www.copasi.org/RDF/MiriamTerms#' xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'>
<rdf:Description rdf:about='#COPASI6'>
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2011-11-08T14:07:51Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
<CopasiMT:is rdf:resource='urn:miriam:obo.chebi:17050'/>
<CopasiMT:is rdf:resource='urn:miriam:obo.chebi:18021'/>
<CopasiMT:is rdf:resource='urn:miriam:obo.chebi:25405'/>
</rdf:Description>
</rdf:RDF>
</COPASI>
<rdf:RDF xmlns:bqbiol='http://biomodels.net/biology-qualifiers/' xmlns:bqmodel='http://biomodels.net/model-qualifiers/' xmlns:dc='http://purl.org/dc/elements/1.1/' xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#' xmlns:vCard='http://www.w3.org/2001/vcard-rdf/3.0#'>
<rdf:Description rdf:about='#COPASI6'>
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource='urn:miriam:obo.chebi:18021'/>
</rdf:Bag>
</bqbiol:is>
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource='urn:miriam:obo.chebi:17050'/>
</rdf:Bag>
</bqbiol:is>
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource='urn:miriam:obo.chebi:25405'/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</species>
<species compartment='compartment_1' id='species_6' initialConcentration='0' metaid='COPASI7' name='pyruvate'>
<annotation>
<COPASI xmlns='http://www.copasi.org/static/sbml'>
<rdf:RDF xmlns:CopasiMT='http://www.copasi.org/RDF/MiriamTerms#' xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'>
<rdf:Description rdf:about='#COPASI7'>
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2011-11-08T14:08:25Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
<CopasiMT:is rdf:resource='urn:miriam:obo.chebi:15361'/>
</rdf:Description>
</rdf:RDF>
</COPASI>
<rdf:RDF xmlns:bqbiol='http://biomodels.net/biology-qualifiers/' xmlns:bqmodel='http://biomodels.net/model-qualifiers/' xmlns:dc='http://purl.org/dc/elements/1.1/' xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#' xmlns:vCard='http://www.w3.org/2001/vcard-rdf/3.0#'>
<rdf:Description rdf:about='#COPASI7'>
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource='urn:miriam:obo.chebi:15361'/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</species>
<species compartment='compartment_1' id='species_7' initialConcentration='20.0119171920931' metaid='COPASI8' name='Pi intra'>
<annotation>
<COPASI xmlns='http://www.copasi.org/static/sbml'>
<rdf:RDF xmlns:CopasiMT='http://www.copasi.org/RDF/MiriamTerms#' xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'>
<rdf:Description rdf:about='#COPASI8'>
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2011-11-08T14:10:33Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
<CopasiMT:is rdf:resource='urn:miriam:obo.chebi:18367'/>
</rdf:Description>
</rdf:RDF>
</COPASI>
<rdf:RDF xmlns:bqbiol='http://biomodels.net/biology-qualifiers/' xmlns:bqmodel='http://biomodels.net/model-qualifiers/' xmlns:dc='http://purl.org/dc/elements/1.1/' xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#' xmlns:vCard='http://www.w3.org/2001/vcard-rdf/3.0#'>
<rdf:Description rdf:about='#COPASI8'>
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource='urn:miriam:obo.chebi:18367'/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</species>
<species compartment='compartment_1' id='species_8' initialConcentration='6.40762186507293' metaid='COPASI9' name='ADP'>
<annotation>
<COPASI xmlns='http://www.copasi.org/static/sbml'>
<rdf:RDF xmlns:CopasiMT='http://www.copasi.org/RDF/MiriamTerms#' xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'>
<rdf:Description rdf:about='#COPASI9'>
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2011-02-16T10:09:02Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
<CopasiMT:is rdf:resource='urn:miriam:obo.chebi:16761'/>
</rdf:Description>
</rdf:RDF>
</COPASI>
<rdf:RDF xmlns:bqbiol='http://biomodels.net/biology-qualifiers/' xmlns:bqmodel='http://biomodels.net/model-qualifiers/' xmlns:dc='http://purl.org/dc/elements/1.1/' xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#' xmlns:vCard='http://www.w3.org/2001/vcard-rdf/3.0#'>
<rdf:Description rdf:about='#COPASI9'>
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource='urn:miriam:obo.chebi:16761'/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</species>
<species compartment='compartment_1' id='species_9' initialConcentration='8.99981677831351' metaid='COPASI10' name='ATP'>
<annotation>
<COPASI xmlns='http://www.copasi.org/static/sbml'>
<rdf:RDF xmlns:CopasiMT='http://www.copasi.org/RDF/MiriamTerms#' xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'>
<rdf:Description rdf:about='#COPASI10'>
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2011-04-13T11:14:08Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
<CopasiMT:is rdf:resource='urn:miriam:obo.chebi:15422'/>
</rdf:Description>
</rdf:RDF>
</COPASI>
<rdf:RDF xmlns:bqbiol='http://biomodels.net/biology-qualifiers/' xmlns:bqmodel='http://biomodels.net/model-qualifiers/' xmlns:dc='http://purl.org/dc/elements/1.1/' xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#' xmlns:vCard='http://www.w3.org/2001/vcard-rdf/3.0#'>
<rdf:Description rdf:about='#COPASI10'>
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource='urn:miriam:obo.chebi:15422'/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</species>
<species compartment='compartment_1' id='species_10' initialConcentration='0.254709040235568' metaid='COPASI11' name='NAD'>
<annotation>
<COPASI xmlns='http://www.copasi.org/static/sbml'>
<rdf:RDF xmlns:CopasiMT='http://www.copasi.org/RDF/MiriamTerms#' xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'>
<rdf:Description rdf:about='#COPASI11'>
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2011-11-08T14:08:49Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
<CopasiMT:is rdf:resource='urn:miriam:obo.chebi:15846'/>
</rdf:Description>
</rdf:RDF>
</COPASI>
<rdf:RDF xmlns:bqbiol='http://biomodels.net/biology-qualifiers/' xmlns:bqmodel='http://biomodels.net/model-qualifiers/' xmlns:dc='http://purl.org/dc/elements/1.1/' xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#' xmlns:vCard='http://www.w3.org/2001/vcard-rdf/3.0#'>
<rdf:Description rdf:about='#COPASI11'>
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource='urn:miriam:obo.chebi:15846'/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</species>
<species compartment='compartment_1' id='species_11' initialConcentration='0' metaid='COPASI12' name='NADH'>
<annotation>
<COPASI xmlns='http://www.copasi.org/static/sbml'>
<rdf:RDF xmlns:CopasiMT='http://www.copasi.org/RDF/MiriamTerms#' xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'>
<rdf:Description rdf:about='#COPASI12'>
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2011-11-08T14:08:37Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
<CopasiMT:is rdf:resource='urn:miriam:obo.chebi:16908'/>
</rdf:Description>
</rdf:RDF>
</COPASI>
<rdf:RDF xmlns:bqbiol='http://biomodels.net/biology-qualifiers/' xmlns:bqmodel='http://biomodels.net/model-qualifiers/' xmlns:dc='http://purl.org/dc/elements/1.1/' xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#' xmlns:vCard='http://www.w3.org/2001/vcard-rdf/3.0#'>
<rdf:Description rdf:about='#COPASI12'>
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource='urn:miriam:obo.chebi:16908'/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</species>
<species compartment='compartment_2' id='species_12' initialConcentration='0.00214776436093551' metaid='COPASI13' name='lactate'>
<annotation>
<COPASI xmlns='http://www.copasi.org/static/sbml'>
<rdf:RDF xmlns:CopasiMT='http://www.copasi.org/RDF/MiriamTerms#' xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'>
<rdf:Description rdf:about='#COPASI13'>
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2011-11-08T14:09:00Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
<CopasiMT:is rdf:resource='urn:miriam:obo.chebi:24996'/>
</rdf:Description>
</rdf:RDF>
</COPASI>
<rdf:RDF xmlns:bqbiol='http://biomodels.net/biology-qualifiers/' xmlns:bqmodel='http://biomodels.net/model-qualifiers/' xmlns:dc='http://purl.org/dc/elements/1.1/' xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#' xmlns:vCard='http://www.w3.org/2001/vcard-rdf/3.0#'>
<rdf:Description rdf:about='#COPASI13'>
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource='urn:miriam:obo.chebi:24996'/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</species>
<species compartment='compartment_2' id='species_13' initialConcentration='0' metaid='COPASI14' name='Pi extra'>
<annotation>
<COPASI xmlns='http://www.copasi.org/static/sbml'>
<rdf:RDF xmlns:CopasiMT='http://www.copasi.org/RDF/MiriamTerms#' xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'>
<rdf:Description rdf:about='#COPASI14'>
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2011-11-08T14:10:43Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
<CopasiMT:is rdf:resource='urn:miriam:obo.chebi:18367'/>
</rdf:Description>
</rdf:RDF>
</COPASI>
<rdf:RDF xmlns:bqbiol='http://biomodels.net/biology-qualifiers/' xmlns:bqmodel='http://biomodels.net/model-qualifiers/' xmlns:dc='http://purl.org/dc/elements/1.1/' xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#' xmlns:vCard='http://www.w3.org/2001/vcard-rdf/3.0#'>
<rdf:Description rdf:about='#COPASI14'>
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource='urn:miriam:obo.chebi:18367'/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</species>
<species compartment='compartment_2' id='species_14' initialConcentration='0' metaid='COPASI15' name='mixed acids'>
<annotation>
<COPASI xmlns='http://www.copasi.org/static/sbml'>
<rdf:RDF xmlns:CopasiMT='http://www.copasi.org/RDF/MiriamTerms#' xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'>
<rdf:Description rdf:about='#COPASI15'>
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2011-11-08T14:02:30Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
<CopasiMT:is rdf:resource='urn:miriam:obo.chebi:15351'/>
<CopasiMT:is rdf:resource='urn:miriam:obo.chebi:16236'/>
<CopasiMT:is rdf:resource='urn:miriam:obo.chebi:30089'/>
<CopasiMT:is rdf:resource='urn:miriam:obo.chebi:30751'/>
</rdf:Description>
</rdf:RDF>
</COPASI>
<rdf:RDF xmlns:bqbiol='http://biomodels.net/biology-qualifiers/' xmlns:bqmodel='http://biomodels.net/model-qualifiers/' xmlns:dc='http://purl.org/dc/elements/1.1/' xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#' xmlns:vCard='http://www.w3.org/2001/vcard-rdf/3.0#'>
<rdf:Description rdf:about='#COPASI15'>
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource='urn:miriam:obo.chebi:16236'/>
</rdf:Bag>
</bqbiol:is>
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource='urn:miriam:obo.chebi:30751'/>
</rdf:Bag>
</bqbiol:is>
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource='urn:miriam:obo.chebi:30089'/>
</rdf:Bag>
</bqbiol:is>
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource='urn:miriam:obo.chebi:15351'/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</species>
<species compartment='compartment_2' id='species_15' initialConcentration='1' metaid='COPASI16' name='Glucose'>
<annotation>
<COPASI xmlns='http://www.copasi.org/static/sbml'>
<rdf:RDF xmlns:CopasiMT='http://www.copasi.org/RDF/MiriamTerms#' xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'>
<rdf:Description rdf:about='#COPASI16'>
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2011-11-08T14:09:12Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
<CopasiMT:is rdf:resource='urn:miriam:obo.chebi:17234'/>
</rdf:Description>
</rdf:RDF>
</COPASI>
<rdf:RDF xmlns:bqbiol='http://biomodels.net/biology-qualifiers/' xmlns:bqmodel='http://biomodels.net/model-qualifiers/' xmlns:dc='http://purl.org/dc/elements/1.1/' xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#' xmlns:vCard='http://www.w3.org/2001/vcard-rdf/3.0#'>
<rdf:Description rdf:about='#COPASI16'>
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource='urn:miriam:obo.chebi:17234'/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</species>
</listOfSpecies>
<listOfReactions>
<reaction id='reaction_1' metaid='COPASI17' name='pfk' reversible='false'>
<annotation>
<COPASI xmlns='http://www.copasi.org/static/sbml'>
<rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'>
<rdf:Description rdf:about='#COPASI17'>
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2010-12-21T13:17:48Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfReactants>
<speciesReference species='species_1'/>
<speciesReference species='species_9'/>
</listOfReactants>
<listOfProducts>
<speciesReference species='species_2'/>
<speciesReference species='species_8'/>
</listOfProducts>
<kineticLaw>
<math xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<times/>
<ci> compartment_1 </ci>
<apply>
<ci> function_1 </ci>
<ci> Vmax </ci>
<ci> species_1 </ci>
<ci> KmS1 </ci>
<ci> species_9 </ci>
<ci> KmS2 </ci>
<ci> species_2 </ci>
<ci> KmP1 </ci>
<ci> species_8 </ci>
<ci> KmP2 </ci>
</apply>
</apply>
</math>
<listOfParameters>
<parameter id='Vmax' name='Vmax' value='20.1788'/>
<parameter id='KmS1' name='KmS1' value='0.435043'/>
<parameter id='KmS2' name='KmS2' value='1.24214'/>
<parameter id='KmP1' name='KmP1' value='57.9978'/>
<parameter id='KmP2' name='KmP2' value='0.0300039'/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id='reaction_2' metaid='COPASI18' name='fba'>
<annotation>
<COPASI xmlns='http://www.copasi.org/static/sbml'>
<rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'>
<rdf:Description rdf:about='#COPASI18'>
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2010-12-21T13:13:51Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfReactants>
<speciesReference species='species_2'/>
</listOfReactants>
<listOfProducts>
<speciesReference species='species_3' stoichiometry='2'/>
</listOfProducts>
<kineticLaw>
<math xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<times/>
<ci> compartment_1 </ci>
<apply>
<ci> function_2 </ci>
<ci> Vmax </ci>
<ci> species_2 </ci>
<ci> KmS1 </ci>
<ci> Keq </ci>
<ci> KmP1 </ci>
<ci> species_3 </ci>
<ci> species_3 </ci>
</apply>
</apply>
</math>
<listOfParameters>
<parameter id='Vmax' name='Vmax' value='2.64502'/>
<parameter id='KmS1' name='KmS1' value='1.69961'/>
<parameter id='Keq' name='Keq' value='0.056'/>
<parameter id='KmP1' name='KmP1' value='17.6344'/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id='reaction_3' metaid='COPASI19' name='fbpase' reversible='false'>
<annotation>
<COPASI xmlns='http://www.copasi.org/static/sbml'>
<rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'>
<rdf:Description rdf:about='#COPASI19'>
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2010-12-21T13:15:03Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfReactants>
<speciesReference species='species_2'/>
</listOfReactants>
<listOfProducts>
<speciesReference species='species_1'/>
<speciesReference species='species_7'/>
</listOfProducts>
<kineticLaw>
<math xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<times/>
<ci> compartment_1 </ci>
<apply>
<ci> function_3 </ci>
<ci> Vmax </ci>
<ci> species_2 </ci>
<ci> KmS1 </ci>
<ci> species_1 </ci>
<ci> KmP1 </ci>
<ci> species_7 </ci>
<ci> KmP2 </ci>
</apply>
</apply>
</math>
<listOfParameters>
<parameter id='Vmax' name='Vmax' value='183.348'/>
<parameter id='KmS1' name='KmS1' value='48.7658'/>
<parameter id='KmP1' name='KmP1' value='0.0147529'/>
<parameter id='KmP2' name='KmP2' value='10.8927'/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id='reaction_4' metaid='COPASI20' name='gapdh'>
<annotation>
<COPASI xmlns='http://www.copasi.org/static/sbml'>
<rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'>
<rdf:Description rdf:about='#COPASI20'>
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2010-12-21T13:15:47Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfReactants>
<speciesReference species='species_3'/>
<speciesReference species='species_10'/>
<speciesReference species='species_7'/>
</listOfReactants>
<listOfProducts>
<speciesReference species='species_4'/>
<speciesReference species='species_11'/>
</listOfProducts>
<kineticLaw>
<math xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<times/>
<ci> compartment_1 </ci>
<apply>
<ci> function_4 </ci>
<ci> Vmax </ci>
<ci> species_3 </ci>
<ci> KmS1 </ci>
<ci> species_10 </ci>
<ci> KmS2 </ci>
<ci> species_7 </ci>
<ci> KmS3 </ci>
<ci> Keq </ci>
<ci> KmP1 </ci>
<ci> KmP2 </ci>
<ci> species_4 </ci>
<ci> species_11 </ci>
</apply>
</apply>
</math>
<listOfParameters>
<parameter id='Vmax' name='Vmax' value='37.1894'/>
<parameter id='KmS1' name='KmS1' value='0.080501'/>
<parameter id='KmS2' name='KmS2' value='1.71631'/>
<parameter id='KmS3' name='KmS3' value='2.01006'/>
<parameter id='Keq' name='Keq' value='0.0007'/>
<parameter id='KmP1' name='KmP1' value='0.00500025'/>
<parameter id='KmP2' name='KmP2' value='0.0565221'/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id='reaction_5' metaid='COPASI21' name='eno'>
<annotation>
<COPASI xmlns='http://www.copasi.org/static/sbml'>
<rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'>
<rdf:Description rdf:about='#COPASI21'>
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2010-12-21T13:13:18Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfReactants>
<speciesReference species='species_4'/>
<speciesReference species='species_8'/>
</listOfReactants>
<listOfProducts>
<speciesReference species='species_5'/>
<speciesReference species='species_9'/>
</listOfProducts>
<kineticLaw>
<math xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<times/>
<ci> compartment_1 </ci>
<apply>
<ci> function_5 </ci>
<ci> Vmax </ci>
<ci> species_4 </ci>
<ci> KmS1 </ci>
<ci> species_8 </ci>
<ci> KmS2 </ci>
<ci> Keq </ci>
<ci> KmP1 </ci>
<ci> KmP2 </ci>
<ci> species_5 </ci>
<ci> species_9 </ci>
</apply>
</apply>
</math>
<listOfParameters>
<parameter id='Vmax' name='Vmax' value='5.96394'/>
<parameter id='KmS1' name='KmS1' value='0.0184256'/>
<parameter id='KmS2' name='KmS2' value='0.02'/>
<parameter id='Keq' name='Keq' value='27.55'/>
<parameter id='KmP1' name='KmP1' value='0.0598516'/>
<parameter id='KmP2' name='KmP2' value='1.71656'/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id='reaction_6' metaid='COPASI22' name='pyk' reversible='false'>
<annotation>
<COPASI xmlns='http://www.copasi.org/static/sbml'>
<rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'>
<rdf:Description rdf:about='#COPASI22'>
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2010-12-21T13:20:07Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfReactants>
<speciesReference species='species_5'/>
<speciesReference species='species_8'/>
</listOfReactants>
<listOfProducts>
<speciesReference species='species_6'/>
<speciesReference species='species_9'/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species='species_7'/>
<modifierSpeciesReference species='species_2'/>
</listOfModifiers>
<kineticLaw>
<math xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<times/>
<ci> compartment_1 </ci>
<apply>
<ci> function_6 </ci>
<ci> KmMm </ci>
<ci> n </ci>
<ci> species_7 </ci>
<ci> species_2 </ci>
<ci> KmMp </ci>
<ci> Vmax </ci>
<ci> species_5 </ci>
<ci> KmS1 </ci>
<ci> species_8 </ci>
<ci> KmS2 </ci>
<ci> species_6 </ci>
<ci> KmP1 </ci>
<ci> species_9 </ci>
<ci> KmP2 </ci>
</apply>
</apply>
</math>
<listOfParameters>
<parameter id='KmMm' name='KmMm' value='12.3101'/>
<parameter id='n' name='n' value='3'/>
<parameter id='KmMp' name='KmMp' value='0.732078'/>
<parameter id='Vmax' name='Vmax' value='28.4132'/>
<parameter id='KmS1' name='KmS1' value='0.0957467'/>
<parameter id='KmS2' name='KmS2' value='8.06159'/>
<parameter id='KmP1' name='KmP1' value='80.2894'/>
<parameter id='KmP2' name='KmP2' value='13.267'/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id='reaction_7' metaid='COPASI23' name='ldh' reversible='false'>
<annotation>
<COPASI xmlns='http://www.copasi.org/static/sbml'>
<rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'>
<rdf:Description rdf:about='#COPASI23'>
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2010-12-21T13:16:24Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfReactants>
<speciesReference species='species_6'/>
<speciesReference species='species_11'/>
</listOfReactants>
<listOfProducts>
<speciesReference species='species_12'/>
<speciesReference species='species_10'/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species='species_2'/>
<modifierSpeciesReference species='species_7'/>
</listOfModifiers>
<kineticLaw>
<math xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<ci> function_7 </ci>
<ci> species_2 </ci>
<ci> species_7 </ci>
<ci> Km_FBPPi </ci>
<ci> Vmax </ci>
<ci> species_6 </ci>
<ci> KmS1 </ci>
<ci> species_11 </ci>
<ci> KmS2 </ci>
<ci> species_12 </ci>
<ci> KmP1 </ci>
<ci> species_10 </ci>
<ci> KmP2 </ci>
</apply>
</math>
<listOfParameters>
<parameter id='Km_FBPPi' name='Km_FBPPi' value='0.00020138'/>
<parameter id='Vmax' name='Vmax' value='996.558'/>
<parameter id='KmS1' name='KmS1' value='0.664325'/>
<parameter id='KmS2' name='KmS2' value='0.020014'/>
<parameter id='KmP1' name='KmP1' value='99.8592'/>
<parameter id='KmP2' name='KmP2' value='21.7749'/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id='reaction_8' metaid='COPASI24' name='atpase' reversible='false'>
<annotation>
<COPASI xmlns='http://www.copasi.org/static/sbml'>
<rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'>
<rdf:Description rdf:about='#COPASI24'>
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2010-12-21T13:13:02Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfReactants>
<speciesReference species='species_9'/>
</listOfReactants>
<listOfProducts>
<speciesReference species='species_8'/>
<speciesReference species='species_7'/>
</listOfProducts>
<kineticLaw>
<math xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<times/>
<ci> compartment_1 </ci>
<apply>
<ci> function_8 </ci>
<ci> Vmax </ci>
<ci> species_9 </ci>
<ci> KmS1 </ci>
<ci> n </ci>
</apply>
</apply>
</math>
<listOfParameters>
<parameter id='Vmax' name='Vmax' value='0.0124696'/>
<parameter id='KmS1' name='KmS1' value='4.65629'/>
<parameter id='n' name='n' value='3'/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id='reaction_9' metaid='COPASI25' name='Pi transport' reversible='false'>
<annotation>
<COPASI xmlns='http://www.copasi.org/static/sbml'>
<rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'>
<rdf:Description rdf:about='#COPASI25'>
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2010-12-21T13:19:49Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfReactants>
<speciesReference species='species_13'/>
<speciesReference species='species_9'/>
</listOfReactants>
<listOfProducts>
<speciesReference species='species_7' stoichiometry='2'/>
<speciesReference species='species_8'/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species='species_7'/>
</listOfModifiers>
<kineticLaw>
<math xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<ci> function_9 </ci>
<ci> Ki </ci>
<ci> species_7 </ci>
<ci> Vmax </ci>
<ci> species_13 </ci>
<ci> KmS1 </ci>
<ci> species_9 </ci>
<ci> KmS2 </ci>
<ci> species_8 </ci>
<ci> KmP1 </ci>
<ci> species_7 </ci>
<ci> KmP2 </ci>
<ci> species_7 </ci>
</apply>
</math>
<listOfParameters>
<parameter id='Ki' name='Ki' value='0.885733'/>
<parameter id='Vmax' name='Vmax' value='1.91757'/>
<parameter id='KmS1' name='KmS1' value='8.91361'/>
<parameter id='KmS2' name='KmS2' value='5.84632'/>
<parameter id='KmP1' name='KmP1' value='90.6089'/>
<parameter id='KmP2' name='KmP2' value='0.205858'/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id='reaction_10' metaid='COPASI26' name='mab' reversible='false'>
<annotation>
<COPASI xmlns='http://www.copasi.org/static/sbml'>
<rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'>
<rdf:Description rdf:about='#COPASI26'>
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2010-12-21T13:18:09Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfReactants>
<speciesReference species='species_6' stoichiometry='2'/>
<speciesReference species='species_11' stoichiometry='2'/>
<speciesReference species='species_8'/>
<speciesReference species='species_7'/>
</listOfReactants>
<listOfProducts>
<speciesReference species='species_14' stoichiometry='2'/>
<speciesReference species='species_10' stoichiometry='2'/>
<speciesReference species='species_9'/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species='species_3'/>
</listOfModifiers>
<kineticLaw>
<math xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<ci> function_10 </ci>
<ci> Km_trioseP </ci>
<ci> n </ci>
<ci> species_3 </ci>
<ci> Vmax </ci>
<ci> species_6 </ci>
<ci> Km_pyruvate </ci>
<ci> species_11 </ci>
<ci> Km_NADH </ci>
<ci> species_8 </ci>
<ci> Km_ADP </ci>
<ci> species_7 </ci>
<ci> Km_Pi </ci>
<ci> species_14 </ci>
<ci> Km_mixedacid </ci>
<ci> species_10 </ci>
<ci> Km_NAD </ci>
<ci> species_9 </ci>
<ci> Km_ATP </ci>
</apply>
</math>
<listOfParameters>
<parameter id='Km_trioseP' name='Km_trioseP' value='0.000636807'/>
<parameter id='n' name='n' value='3'/>
<parameter id='Vmax' name='Vmax' value='1.98963'/>
<parameter id='Km_pyruvate' name='Km_pyruvate' value='0.512794'/>
<parameter id='Km_NADH' name='Km_NADH' value='0.595578'/>
<parameter id='Km_ADP' name='Km_ADP' value='0.0010005'/>
<parameter id='Km_Pi' name='Km_Pi' value='98.5706'/>
<parameter id='Km_mixedacid' name='Km_mixedacid' value='34.4637'/>
<parameter id='Km_NAD' name='Km_NAD' value='0.0366518'/>
<parameter id='Km_ATP' name='Km_ATP' value='97.0156'/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id='reaction_11' metaid='COPASI27' name='pts' reversible='false'>
<annotation>
<COPASI xmlns='http://www.copasi.org/static/sbml'>
<rdf:RDF xmlns:dcterms='http://purl.org/dc/terms/' xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'>
<rdf:Description rdf:about='#COPASI27'>
<dcterms:created>
<rdf:Description>
<dcterms:W3CDTF>2011-08-30T17:49:10Z</dcterms:W3CDTF>
</rdf:Description>
</dcterms:created>
</rdf:Description>
</rdf:RDF>
</COPASI>
</annotation>
<listOfReactants>
<speciesReference species='species_15'/>
<speciesReference species='species_5'/>
</listOfReactants>
<listOfProducts>
<speciesReference species='species_1'/>
<speciesReference species='species_6'/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species='species_2'/>
<modifierSpeciesReference species='species_7'/>
</listOfModifiers>
<kineticLaw>
<math xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<ci> function_11 </ci>
<ci> KmMm </ci>
<ci> species_2 </ci>
<ci> species_7 </ci>
<ci> KmMp </ci>
<ci> Vmax </ci>
<ci> species_15 </ci>
<ci> KmS1 </ci>
<ci> species_5 </ci>
<ci> KmS2 </ci>
<ci> species_1 </ci>
<ci> KmP1 </ci>
<ci> species_6 </ci>
<ci> KmP2 </ci>
</apply>
</math>
<listOfParameters>
<parameter id='KmMm' name='KmMm' value='30.1418'/>
<parameter id='KmMp' name='KmMp' value='1.0273'/>
<parameter id='Vmax' name='Vmax' value='0.22786'/>
<parameter id='KmS1' name='KmS1' value='0.149998'/>
<parameter id='KmS2' name='KmS2' value='0.0215991'/>
<parameter id='KmP1' name='KmP1' value='99.0911'/>
<parameter id='KmP2' name='KmP2' value='67.0551'/>
</listOfParameters>
</kineticLaw>
</reaction>
</listOfReactions>
</model>
</sbml>
Simulation of levering1.xml |
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| Notes |
Original model source: in JWS online database.
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| Software | http://www.copasi.org (COPASI) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| BioModels or JWS Online ID | levering1 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Export metadata |
RDF:
metadataModelEntryID23.rdf
XML: metadataModelEntryID23.xml Plain text: metadataModelEntryID23.txt |
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species_2 + species_8
Share
|
Cite Model EntryID 23
Cite Model EntryID 23
| APA |
KiMoSys (https://kimosys.org). (2014, November 3). Model EntryID 23 (Lactococcus lactis). https://kimosys.org/repository/37/associated_models/23
|
|
| MLA |
KiMoSys (https://kimosys.org). "Model EntryID 23 (Lactococcus lactis)." 2025, kimosys.org/repository/37/associated_models/23.
|
|
| ISO-690 |
KiMoSys (https://kimosys.org). Model EntryID 23 (Lactococcus lactis). [online], [Accessed 3 November 2025]. Available from: https://kimosys.org/repository/37/associated_models/23
|
|
| BibTeX |
@misc{ KiMoSysModelEntryID23,
author = "{KiMoSys (https://kimosys.org)}",
title = "Model EntryID 23 (Lactococcus lactis)",
url = "https://kimosys.org/repository/37/associated_models/23",
note = "[Online; accessed 3-November-2025]"
}
|
|
Related Model(s): AccessID 24 | AccessID 35 | AccessID 37
Submission and curation
Entered by:
Administrator KiMoSysFirst name: Administrator
Affiliation: INESC-ID/IST
Homepage: http://kdbio.inesc-id.pt/kimosys
Interests: mathematical modeling, accessible data, use of data
Created: 2013-05-06 15:37:33 UTC
Updated: 2014-06-30 17:53:53 UTC
Version: 0
Status: (reviewed) 2013-12-06 17:39:36 UTC
Views: 261
Downloads: 62