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General Information

Manuscript title	Division of labor by dual feedback regulators controls JAK2/STAT5 signaling over broad ligand range.
PubMed ID	21772264
Journal	Molecular Systems Biology
Year	2011
Authors	Julie Bachmann, Andreas Raue, Marcel Schilling, Martin E. Boehm, Clemens Kreutz, Daniel Kaschek, Hauke Busch, Norbert Gretz, Wolf D. Lehmann, Jens Timmer and Ursula Klingmueller
Affiliations	Division of Systems Biology of Signal Transduction, DKFZ-ZMBH Alliance, German Cancer Research Center, Heidelberg, Germany
Keywords	apoptosis, erythropoietin, mathematical modeling, negative feedback, SOCS, simulation and data analysis, signal transduction
Full text article	Bachmann_2011.pdf
Project name	not specified
Data used for	Model building

Model Information

Model name

transcriptional model of JAK2/STAT5 signaling

Organism

Mouse

Model type

ordinary differential equations

Category

Signal

Number of reactions

Number of species

Number of regulators

not specified

Number of parameters

115

Number of compartments

Dilution rate (h^-1)

—

Model file(s) and history

LATEST KIMOMODEL31.xml (2014-04-23 17:30:03 UTC by Administrator KiMoSys ) Preview

<?xml version='1.0' encoding='UTF-8'?>
<sbml level='2' version='1' xmlns='http://www.sbml.org/sbml/level2'>
<model id='jak2_stat5_feedbacks' name='jak2_stat5_feedbacks'>

<notes>
<body xmlns='http://www.w3.org/1999/xhtml'>
<p>SBML model Bachmann et al.</p>
</body>
</notes>
<listOfCompartments>
<compartment constant='true' id='cyt' name='cyt' size='0.4' spatialDimensions='3'/>
<compartment constant='true' id='nuc' name='nuc' size='0.275' spatialDimensions='3'/>
</listOfCompartments>

<listOfSpecies>
<species compartment='cyt' id='EpoRJAK2' initialConcentration='3.97622' name='EpoRJAK2'>
</species>
<species compartment='cyt' id='EpoRpJAK2' initialConcentration='0' name='EpoRpJAK2'>
</species>
<species compartment='cyt' id='p1EpoRpJAK2' initialConcentration='0' name='p1EpoRpJAK2'>
</species>
<species compartment='cyt' id='p2EpoRpJAK2' initialConcentration='0' name='p2EpoRpJAK2'>
</species>
<species compartment='cyt' id='p12EpoRpJAK2' initialConcentration='0' name='p12EpoRpJAK2'>
</species>
<species compartment='cyt' id='EpoRJAK2_CIS' initialConcentration='0' name='EpoRJAK2_CIS'>
</species>
<species compartment='cyt' id='SHP1' initialConcentration='26.7251' name='SHP1'>
</species>
<species compartment='cyt' id='SHP1Act' initialConcentration='0' name='SHP1Act'>
</species>
<species compartment='cyt' id='STAT5' initialConcentration='79.7535' name='STAT5'>
</species>
<species compartment='cyt' id='pSTAT5' initialConcentration='0' name='pSTAT5'>
</species>
<species compartment='nuc' id='npSTAT5' initialConcentration='0' name='npSTAT5'>
</species>
<species compartment='nuc' id='CISnRNA1' initialConcentration='0' name='CISnRNA1'>
</species>
<species compartment='nuc' id='CISnRNA2' initialConcentration='0' name='CISnRNA2'>
</species>
<species compartment='nuc' id='CISnRNA3' initialConcentration='0' name='CISnRNA3'>
</species>
<species compartment='nuc' id='CISnRNA4' initialConcentration='0' name='CISnRNA4'>
</species>
<species compartment='nuc' id='CISnRNA5' initialConcentration='0' name='CISnRNA5'>
</species>
<species compartment='cyt' id='CISRNA' initialConcentration='0' name='CISRNA'>
</species>
<species compartment='cyt' id='CIS' initialConcentration='0' name='CIS'>
</species>
<species compartment='nuc' id='SOCS3nRNA1' initialConcentration='0' name='SOCS3nRNA1'>
</species>
<species compartment='nuc' id='SOCS3nRNA2' initialConcentration='0' name='SOCS3nRNA2'>
</species>
<species compartment='nuc' id='SOCS3nRNA3' initialConcentration='0' name='SOCS3nRNA3'>
</species>
<species compartment='nuc' id='SOCS3nRNA4' initialConcentration='0' name='SOCS3nRNA4'>
</species>
<species compartment='nuc' id='SOCS3nRNA5' initialConcentration='0' name='SOCS3nRNA5'>
</species>
<species compartment='cyt' id='SOCS3RNA' initialConcentration='0' name='SOCS3RNA'>
</species>
<species compartment='cyt' id='SOCS3' initialConcentration='0' name='SOCS3'>
</species>
<species compartment='cyt' id='Epo' initialConcentration='1.24997e-007' name='Epo'>
</species>
</listOfSpecies>

<listOfParameters>
<parameter id='ActD' value='0'/>
<parameter id='CISEqc' value='432.871'/>
<parameter id='CISEqcOE' value='0.530261'/>
<parameter id='CISInh' value='7.84653e+008'/>
<parameter id='CISRNADelay' value='0.144775'/>
<parameter id='CISRNAEqc' value='1'/>
<parameter id='CISRNATurn' value='1000'/>
<parameter id='CISTurn' value='0.00839842'/>
<parameter id='CISoe' value='0'/>
<parameter id='EpoRActJAK2' value='0.267308'/>
<parameter id='EpoRCISInh' value='1e+006'/>
<parameter id='EpoRCISRemove' value='5.42932'/>
<parameter id='JAK2ActEpo' value='633253'/>
<parameter id='JAK2EpoRDeaSHP1' value='142.722'/>
<parameter id='SHP1ActEpoR' value='0.001'/>
<parameter id='SHP1Dea' value='0.00816391'/>
<parameter id='SOCS3Eqc' value='173.653'/>
<parameter id='SOCS3EqcOE' value='0.679157'/>
<parameter id='SOCS3Inh' value='10.408'/>
<parameter id='SOCS3RNADelay' value='1.06465'/>
<parameter id='SOCS3RNAEqc' value='1'/>
<parameter id='SOCS3RNATurn' value='0.00830844'/>
<parameter id='SOCS3Turn' value='10000'/>
<parameter id='SOCS3oe' value='0'/>
<parameter id='STAT5ActEpoR' value='38.9757'/>
<parameter id='STAT5ActJAK2' value='0.0780965'/>
<parameter id='STAT5Exp' value='0.0745155'/>
<parameter id='STAT5Imp' value='0.0268889'/>
<parameter id='epo_level' value='1.24997e-007'/>
<parameter id='init_EpoRJAK2' value='3.97622'/>
<parameter id='init_SHP1' value='26.7251'/>
<parameter id='init_STAT5' value='79.7535'/>
</listOfParameters>

<listOfReactions>

<reaction id='reaction_1' reversible='false'>
    <listOfReactants>
        <speciesReference species='EpoRJAK2'>
        </speciesReference>
    </listOfReactants>
    <listOfProducts>
        <speciesReference species='EpoRpJAK2'>
        </speciesReference>
    </listOfProducts>
    <listOfModifiers>
        <modifierSpeciesReference species='Epo'>
        </modifierSpeciesReference>
        <modifierSpeciesReference species='SOCS3'>
        </modifierSpeciesReference>
    </listOfModifiers>
    <kineticLaw>
        <math xmlns='http://www.w3.org/1998/Math/MathML'>
           <apply><times/><apply><divide/><apply><times/><apply><times/><ci>JAK2ActEpo</ci><ci>Epo</ci></apply><ci>EpoRJAK2</ci></apply><apply><plus/><apply><divide/><apply><times/><ci>SOCS3Inh</ci><ci>SOCS3</ci></apply><ci>SOCS3Eqc</ci></apply><cn>1</cn></apply></apply><ci>cyt</ci></apply>
        </math>
    </kineticLaw>
</reaction>

<reaction id='reaction_2' reversible='false'>
    <listOfReactants>
        <speciesReference species='EpoRpJAK2'>
        </speciesReference>
    </listOfReactants>
    <listOfProducts>
        <speciesReference species='EpoRJAK2'>
        </speciesReference>
    </listOfProducts>
    <listOfModifiers>
        <modifierSpeciesReference species='SHP1Act'>
        </modifierSpeciesReference>
    </listOfModifiers>
    <kineticLaw>
        <math xmlns='http://www.w3.org/1998/Math/MathML'>
           <apply><times/><apply><divide/><apply><times/><apply><times/><ci>JAK2EpoRDeaSHP1</ci><ci>SHP1Act</ci></apply><ci>EpoRpJAK2</ci></apply><ci>init_SHP1</ci></apply><ci>cyt</ci></apply>
        </math>
    </kineticLaw>
</reaction>

<reaction id='reaction_3' reversible='false'>
    <listOfReactants>
        <speciesReference species='EpoRpJAK2'>
        </speciesReference>
    </listOfReactants>
    <listOfProducts>
        <speciesReference species='p1EpoRpJAK2'>
        </speciesReference>
    </listOfProducts>
    <listOfModifiers>
        <modifierSpeciesReference species='SOCS3'>
        </modifierSpeciesReference>
    </listOfModifiers>
    <kineticLaw>
        <math xmlns='http://www.w3.org/1998/Math/MathML'>
           <apply><times/><apply><divide/><apply><times/><ci>EpoRActJAK2</ci><ci>EpoRpJAK2</ci></apply><apply><plus/><apply><divide/><apply><times/><ci>SOCS3Inh</ci><ci>SOCS3</ci></apply><ci>SOCS3Eqc</ci></apply><cn>1</cn></apply></apply><ci>cyt</ci></apply>
        </math>
    </kineticLaw>
</reaction>

<reaction id='reaction_4' reversible='false'>
    <listOfReactants>
        <speciesReference species='EpoRpJAK2'>
        </speciesReference>
    </listOfReactants>
    <listOfProducts>
        <speciesReference species='p2EpoRpJAK2'>
        </speciesReference>
    </listOfProducts>
    <listOfModifiers>
        <modifierSpeciesReference species='EpoRJAK2_CIS'>
        </modifierSpeciesReference>
        <modifierSpeciesReference species='SOCS3'>
        </modifierSpeciesReference>
    </listOfModifiers>
    <kineticLaw>
        <math xmlns='http://www.w3.org/1998/Math/MathML'>
           <apply><times/><apply><divide/><apply><times/><apply><times/><cn>3</cn><ci>EpoRActJAK2</ci></apply><ci>EpoRpJAK2</ci></apply><apply><times/><apply><plus/><apply><divide/><apply><times/><ci>SOCS3Inh</ci><ci>SOCS3</ci></apply><ci>SOCS3Eqc</ci></apply><cn>1</cn></apply><apply><plus/><apply><times/><ci>EpoRCISInh</ci><ci>EpoRJAK2_CIS</ci></apply><cn>1</cn></apply></apply></apply><ci>cyt</ci></apply>
        </math>
    </kineticLaw>
</reaction>

<reaction id='reaction_5' reversible='false'>
    <listOfReactants>
        <speciesReference species='p1EpoRpJAK2'>
        </speciesReference>
    </listOfReactants>
    <listOfProducts>
        <speciesReference species='p12EpoRpJAK2'>
        </speciesReference>
    </listOfProducts>
    <listOfModifiers>
        <modifierSpeciesReference species='EpoRJAK2_CIS'>
        </modifierSpeciesReference>
        <modifierSpeciesReference species='SOCS3'>
        </modifierSpeciesReference>
    </listOfModifiers>
    <kineticLaw>
        <math xmlns='http://www.w3.org/1998/Math/MathML'>
           <apply><times/><apply><divide/><apply><times/><apply><times/><cn>3</cn><ci>EpoRActJAK2</ci></apply><ci>p1EpoRpJAK2</ci></apply><apply><times/><apply><plus/><apply><divide/><apply><times/><ci>SOCS3Inh</ci><ci>SOCS3</ci></apply><ci>SOCS3Eqc</ci></apply><cn>1</cn></apply><apply><plus/><apply><times/><ci>EpoRCISInh</ci><ci>EpoRJAK2_CIS</ci></apply><cn>1</cn></apply></apply></apply><ci>cyt</ci></apply>
        </math>
    </kineticLaw>
</reaction>

<reaction id='reaction_6' reversible='false'>
    <listOfReactants>
        <speciesReference species='p2EpoRpJAK2'>
        </speciesReference>
    </listOfReactants>
    <listOfProducts>
        <speciesReference species='p12EpoRpJAK2'>
        </speciesReference>
    </listOfProducts>
    <listOfModifiers>
        <modifierSpeciesReference species='SOCS3'>
        </modifierSpeciesReference>
    </listOfModifiers>
    <kineticLaw>
        <math xmlns='http://www.w3.org/1998/Math/MathML'>
           <apply><times/><apply><divide/><apply><times/><ci>EpoRActJAK2</ci><ci>p2EpoRpJAK2</ci></apply><apply><plus/><apply><divide/><apply><times/><ci>SOCS3Inh</ci><ci>SOCS3</ci></apply><ci>SOCS3Eqc</ci></apply><cn>1</cn></apply></apply><ci>cyt</ci></apply>
        </math>
    </kineticLaw>
</reaction>

<reaction id='reaction_7' reversible='false'>
    <listOfReactants>
        <speciesReference species='p1EpoRpJAK2'>
        </speciesReference>
    </listOfReactants>
    <listOfProducts>
        <speciesReference species='EpoRJAK2'>
        </speciesReference>
    </listOfProducts>
    <listOfModifiers>
        <modifierSpeciesReference species='SHP1Act'>
        </modifierSpeciesReference>
    </listOfModifiers>
    <kineticLaw>
        <math xmlns='http://www.w3.org/1998/Math/MathML'>
           <apply><times/><apply><divide/><apply><times/><apply><times/><ci>JAK2EpoRDeaSHP1</ci><ci>SHP1Act</ci></apply><ci>p1EpoRpJAK2</ci></apply><ci>init_SHP1</ci></apply><ci>cyt</ci></apply>
        </math>
    </kineticLaw>
</reaction>

<reaction id='reaction_8' reversible='false'>
    <listOfReactants>
        <speciesReference species='p2EpoRpJAK2'>
        </speciesReference>
    </listOfReactants>
    <listOfProducts>
        <speciesReference species='EpoRJAK2'>
        </speciesReference>
    </listOfProducts>
    <listOfModifiers>
        <modifierSpeciesReference species='SHP1Act'>
        </modifierSpeciesReference>
    </listOfModifiers>
    <kineticLaw>
        <math xmlns='http://www.w3.org/1998/Math/MathML'>
           <apply><times/><apply><divide/><apply><times/><apply><times/><ci>JAK2EpoRDeaSHP1</ci><ci>SHP1Act</ci></apply><ci>p2EpoRpJAK2</ci></apply><ci>init_SHP1</ci></apply><ci>cyt</ci></apply>
        </math>
    </kineticLaw>
</reaction>

<reaction id='reaction_9' reversible='false'>
    <listOfReactants>
        <speciesReference species='p12EpoRpJAK2'>
        </speciesReference>
    </listOfReactants>
    <listOfProducts>
        <speciesReference species='EpoRJAK2'>
        </speciesReference>
    </listOfProducts>
    <listOfModifiers>
        <modifierSpeciesReference species='SHP1Act'>
        </modifierSpeciesReference>
    </listOfModifiers>
    <kineticLaw>
        <math xmlns='http://www.w3.org/1998/Math/MathML'>
           <apply><times/><apply><divide/><apply><times/><apply><times/><ci>JAK2EpoRDeaSHP1</ci><ci>SHP1Act</ci></apply><ci>p12EpoRpJAK2</ci></apply><ci>init_SHP1</ci></apply><ci>cyt</ci></apply>
        </math>
    </kineticLaw>
</reaction>

<reaction id='reaction_10' reversible='false'>
    <listOfReactants>
        <speciesReference species='EpoRJAK2_CIS'>
        </speciesReference>
    </listOfReactants>
    <listOfModifiers>
        <modifierSpeciesReference species='p12EpoRpJAK2'>
        </modifierSpeciesReference>
        <modifierSpeciesReference species='p1EpoRpJAK2'>
        </modifierSpeciesReference>
    </listOfModifiers>
    <kineticLaw>
        <math xmlns='http://www.w3.org/1998/Math/MathML'>
           <apply><times/><apply><divide/><apply><times/><apply><times/><ci>EpoRCISRemove</ci><ci>EpoRJAK2_CIS</ci></apply><apply><plus/><ci>p12EpoRpJAK2</ci><ci>p1EpoRpJAK2</ci></apply></apply><ci>init_EpoRJAK2</ci></apply><ci>cyt</ci></apply>
        </math>
    </kineticLaw>
</reaction>

<reaction id='reaction_11' reversible='false'>
    <listOfReactants>
        <speciesReference species='SHP1'>
        </speciesReference>
    </listOfReactants>
    <listOfProducts>
        <speciesReference species='SHP1Act'>
        </speciesReference>
    </listOfProducts>
    <listOfModifiers>
        <modifierSpeciesReference species='EpoRpJAK2'>
        </modifierSpeciesReference>
        <modifierSpeciesReference species='p12EpoRpJAK2'>
        </modifierSpeciesReference>
        <modifierSpeciesReference species='p1EpoRpJAK2'>
        </modifierSpeciesReference>
        <modifierSpeciesReference species='p2EpoRpJAK2'>
        </modifierSpeciesReference>
    </listOfModifiers>
    <kineticLaw>
        <math xmlns='http://www.w3.org/1998/Math/MathML'>
           <apply><times/><apply><divide/><apply><times/><apply><times/><ci>SHP1ActEpoR</ci><ci>SHP1</ci></apply><apply><plus/><apply><plus/><apply><plus/><ci>EpoRpJAK2</ci><ci>p12EpoRpJAK2</ci></apply><ci>p1EpoRpJAK2</ci></apply><ci>p2EpoRpJAK2</ci></apply></apply><ci>init_EpoRJAK2</ci></apply><ci>cyt</ci></apply>
        </math>
    </kineticLaw>
</reaction>

<reaction id='reaction_12' reversible='false'>
    <listOfReactants>
        <speciesReference species='SHP1Act'>
        </speciesReference>
    </listOfReactants>
    <listOfProducts>
        <speciesReference species='SHP1'>
        </speciesReference>
    </listOfProducts>
    <kineticLaw>
        <math xmlns='http://www.w3.org/1998/Math/MathML'>
           <apply><times/><apply><times/><ci>SHP1Dea</ci><ci>SHP1Act</ci></apply><ci>cyt</ci></apply>
        </math>
    </kineticLaw>
</reaction>

<reaction id='reaction_13' reversible='false'>
    <listOfReactants>
        <speciesReference species='STAT5'>
        </speciesReference>
    </listOfReactants>
    <listOfProducts>
        <speciesReference species='pSTAT5'>
        </speciesReference>
    </listOfProducts>
    <listOfModifiers>
        <modifierSpeciesReference species='EpoRpJAK2'>
        </modifierSpeciesReference>
        <modifierSpeciesReference species='SOCS3'>
        </modifierSpeciesReference>
        <modifierSpeciesReference species='p12EpoRpJAK2'>
        </modifierSpeciesReference>
        <modifierSpeciesReference species='p1EpoRpJAK2'>
        </modifierSpeciesReference>
        <modifierSpeciesReference species='p2EpoRpJAK2'>
        </modifierSpeciesReference>
    </listOfModifiers>
    <kineticLaw>
        <math xmlns='http://www.w3.org/1998/Math/MathML'>
           <apply><times/><apply><divide/><apply><times/><apply><times/><ci>STAT5ActJAK2</ci><ci>STAT5</ci></apply><apply><plus/><apply><plus/><apply><plus/><ci>EpoRpJAK2</ci><ci>p12EpoRpJAK2</ci></apply><ci>p1EpoRpJAK2</ci></apply><ci>p2EpoRpJAK2</ci></apply></apply><apply><times/><ci>init_EpoRJAK2</ci><apply><plus/><apply><divide/><apply><times/><ci>SOCS3Inh</ci><ci>SOCS3</ci></apply><ci>SOCS3Eqc</ci></apply><cn>1</cn></apply></apply></apply><ci>cyt</ci></apply>
        </math>
    </kineticLaw>
</reaction>

<reaction id='reaction_14' reversible='false'>
    <listOfReactants>
        <speciesReference species='STAT5'>
        </speciesReference>
    </listOfReactants>
    <listOfProducts>
        <speciesReference species='pSTAT5'>
        </speciesReference>
    </listOfProducts>
    <listOfModifiers>
        <modifierSpeciesReference species='CIS'>
        </modifierSpeciesReference>
        <modifierSpeciesReference species='SOCS3'>
        </modifierSpeciesReference>
        <modifierSpeciesReference species='p12EpoRpJAK2'>
        </modifierSpeciesReference>
        <modifierSpeciesReference species='p1EpoRpJAK2'>
        </modifierSpeciesReference>
    </listOfModifiers>
    <kineticLaw>
        <math xmlns='http://www.w3.org/1998/Math/MathML'>
           <apply><times/><apply><divide/><apply><times/><apply><times/><ci>STAT5ActEpoR</ci><ci>STAT5</ci></apply><apply><power/><apply><plus/><ci>p12EpoRpJAK2</ci><ci>p1EpoRpJAK2</ci></apply><cn>2</cn></apply></apply><apply><times/><apply><times/><apply><power/><ci>init_EpoRJAK2</ci><cn>2</cn></apply><apply><plus/><apply><divide/><apply><times/><ci>CISInh</ci><ci>CIS</ci></apply><ci>CISEqc</ci></apply><cn>1</cn></apply></apply><apply><plus/><apply><divide/><apply><times/><ci>SOCS3Inh</ci><ci>SOCS3</ci></apply><ci>SOCS3Eqc</ci></apply><cn>1</cn></apply></apply></apply><ci>cyt</ci></apply>
        </math>
    </kineticLaw>
</reaction>

<reaction id='reaction_15' reversible='false'>
    <listOfReactants>
        <speciesReference species='pSTAT5'>
        </speciesReference>
    </listOfReactants>
    <listOfProducts>
        <speciesReference species='npSTAT5'>
        </speciesReference>
    </listOfProducts>
    <kineticLaw>
        <math xmlns='http://www.w3.org/1998/Math/MathML'>
           <apply><times/><apply><times/><ci>STAT5Imp</ci><ci>pSTAT5</ci></apply><ci>cyt</ci></apply>
        </math>
    </kineticLaw>
</reaction>

<reaction id='reaction_16' reversible='false'>
    <listOfReactants>
        <speciesReference species='npSTAT5'>
        </speciesReference>
    </listOfReactants>
    <listOfProducts>
        <speciesReference species='STAT5'>
        </speciesReference>
    </listOfProducts>
    <kineticLaw>
        <math xmlns='http://www.w3.org/1998/Math/MathML'>
           <apply><times/><apply><times/><ci>STAT5Exp</ci><ci>npSTAT5</ci></apply><ci>nuc</ci></apply>
        </math>
    </kineticLaw>
</reaction>

<reaction id='reaction_17' reversible='true'>
    <listOfProducts>
        <speciesReference species='CISnRNA1'>
        </speciesReference>
    </listOfProducts>
    <listOfModifiers>
        <modifierSpeciesReference species='npSTAT5'>
        </modifierSpeciesReference>
    </listOfModifiers>
    <kineticLaw>
        <math xmlns='http://www.w3.org/1998/Math/MathML'>
           <apply><minus/><apply><times/><apply><divide/><apply><times/><apply><times/><apply><times/><ci>CISRNAEqc</ci><ci>CISRNATurn</ci></apply><ci>npSTAT5</ci></apply><apply><minus/><ci>ActD</ci><cn>1</cn></apply></apply><ci>init_STAT5</ci></apply><ci>nuc</ci></apply></apply>
        </math>
    </kineticLaw>
</reaction>

<reaction id='reaction_18' reversible='false'>
    <listOfReactants>
        <speciesReference species='CISnRNA1'>
        </speciesReference>
    </listOfReactants>
    <listOfProducts>
        <speciesReference species='CISnRNA2'>
        </speciesReference>
    </listOfProducts>
    <kineticLaw>
        <math xmlns='http://www.w3.org/1998/Math/MathML'>
           <apply><times/><apply><times/><ci>CISRNADelay</ci><ci>CISnRNA1</ci></apply><ci>nuc</ci></apply>
        </math>
    </kineticLaw>
</reaction>

<reaction id='reaction_19' reversible='false'>
    <listOfReactants>
        <speciesReference species='CISnRNA2'>
        </speciesReference>
    </listOfReactants>
    <listOfProducts>
        <speciesReference species='CISnRNA3'>
        </speciesReference>
    </listOfProducts>
    <kineticLaw>
        <math xmlns='http://www.w3.org/1998/Math/MathML'>
           <apply><times/><apply><times/><ci>CISRNADelay</ci><ci>CISnRNA2</ci></apply><ci>nuc</ci></apply>
        </math>
    </kineticLaw>
</reaction>

<reaction id='reaction_20' reversible='false'>
    <listOfReactants>
        <speciesReference species='CISnRNA3'>
        </speciesReference>
    </listOfReactants>
    <listOfProducts>
        <speciesReference species='CISnRNA4'>
        </speciesReference>
    </listOfProducts>
    <kineticLaw>
        <math xmlns='http://www.w3.org/1998/Math/MathML'>
           <apply><times/><apply><times/><ci>CISRNADelay</ci><ci>CISnRNA3</ci></apply><ci>nuc</ci></apply>
        </math>
    </kineticLaw>
</reaction>

<reaction id='reaction_21' reversible='false'>
    <listOfReactants>
        <speciesReference species='CISnRNA4'>
        </speciesReference>
    </listOfReactants>
    <listOfProducts>
        <speciesReference species='CISnRNA5'>
        </speciesReference>
    </listOfProducts>
    <kineticLaw>
        <math xmlns='http://www.w3.org/1998/Math/MathML'>
           <apply><times/><apply><times/><ci>CISRNADelay</ci><ci>CISnRNA4</ci></apply><ci>nuc</ci></apply>
        </math>
    </kineticLaw>
</reaction>

<reaction id='reaction_22' reversible='false'>
    <listOfReactants>
        <speciesReference species='CISnRNA5'>
        </speciesReference>
    </listOfReactants>
    <listOfProducts>
        <speciesReference species='CISRNA'>
        </speciesReference>
    </listOfProducts>
    <kineticLaw>
        <math xmlns='http://www.w3.org/1998/Math/MathML'>
           <apply><times/><apply><times/><ci>CISRNADelay</ci><ci>CISnRNA5</ci></apply><ci>nuc</ci></apply>
        </math>
    </kineticLaw>
</reaction>

<reaction id='reaction_23' reversible='false'>
    <listOfReactants>
        <speciesReference species='CISRNA'>
        </speciesReference>
    </listOfReactants>
    <kineticLaw>
        <math xmlns='http://www.w3.org/1998/Math/MathML'>
           <apply><times/><apply><times/><ci>CISRNATurn</ci><ci>CISRNA</ci></apply><ci>cyt</ci></apply>
        </math>
    </kineticLaw>
</reaction>

<reaction id='reaction_24' reversible='false'>
    <listOfProducts>
        <speciesReference species='CIS'>
        </speciesReference>
    </listOfProducts>
    <listOfModifiers>
        <modifierSpeciesReference species='CISRNA'>
        </modifierSpeciesReference>
    </listOfModifiers>
    <kineticLaw>
        <math xmlns='http://www.w3.org/1998/Math/MathML'>
           <apply><times/><apply><divide/><apply><times/><apply><times/><ci>CISEqc</ci><ci>CISTurn</ci></apply><ci>CISRNA</ci></apply><ci>CISRNAEqc</ci></apply><ci>cyt</ci></apply>
        </math>
    </kineticLaw>
</reaction>

<reaction id='reaction_25' reversible='false'>
    <listOfReactants>
        <speciesReference species='CIS'>
        </speciesReference>
    </listOfReactants>
    <kineticLaw>
        <math xmlns='http://www.w3.org/1998/Math/MathML'>
           <apply><times/><apply><times/><ci>CISTurn</ci><ci>CIS</ci></apply><ci>cyt</ci></apply>
        </math>
    </kineticLaw>
</reaction>

<reaction id='reaction_26' reversible='false'>
    <listOfProducts>
        <speciesReference species='CIS'>
        </speciesReference>
    </listOfProducts>
    <kineticLaw>
        <math xmlns='http://www.w3.org/1998/Math/MathML'>
           <apply><times/><apply><times/><apply><times/><ci>CISoe</ci><ci>CISEqc</ci></apply><ci>CISTurn</ci></apply><ci>CISEqcOE</ci></apply>
        </math>
    </kineticLaw>
</reaction>

<reaction id='reaction_27' reversible='true'>
    <listOfProducts>
        <speciesReference species='SOCS3nRNA1'>
        </speciesReference>
    </listOfProducts>
    <listOfModifiers>
        <modifierSpeciesReference species='npSTAT5'>
        </modifierSpeciesReference>
    </listOfModifiers>
    <kineticLaw>
        <math xmlns='http://www.w3.org/1998/Math/MathML'>
           <apply><minus/><apply><times/><apply><divide/><apply><times/><apply><times/><apply><times/><ci>SOCS3RNAEqc</ci><ci>SOCS3RNATurn</ci></apply><ci>npSTAT5</ci></apply><apply><minus/><ci>ActD</ci><cn>1</cn></apply></apply><ci>init_STAT5</ci></apply><ci>nuc</ci></apply></apply>
        </math>
    </kineticLaw>
</reaction>

<reaction id='reaction_28' reversible='false'>
    <listOfReactants>
        <speciesReference species='SOCS3nRNA1'>
        </speciesReference>
    </listOfReactants>
    <listOfProducts>
        <speciesReference species='SOCS3nRNA2'>
        </speciesReference>
    </listOfProducts>
    <kineticLaw>
        <math xmlns='http://www.w3.org/1998/Math/MathML'>
           <apply><times/><apply><times/><ci>SOCS3RNADelay</ci><ci>SOCS3nRNA1</ci></apply><ci>nuc</ci></apply>
        </math>
    </kineticLaw>
</reaction>

<reaction id='reaction_29' reversible='false'>
    <listOfReactants>
        <speciesReference species='SOCS3nRNA2'>
        </speciesReference>
    </listOfReactants>
    <listOfProducts>
        <speciesReference species='SOCS3nRNA3'>
        </speciesReference>
    </listOfProducts>
    <kineticLaw>
        <math xmlns='http://www.w3.org/1998/Math/MathML'>
           <apply><times/><apply><times/><ci>SOCS3RNADelay</ci><ci>SOCS3nRNA2</ci></apply><ci>nuc</ci></apply>
        </math>
    </kineticLaw>
</reaction>

<reaction id='reaction_30' reversible='false'>
    <listOfReactants>
        <speciesReference species='SOCS3nRNA3'>
        </speciesReference>
    </listOfReactants>
    <listOfProducts>
        <speciesReference species='SOCS3nRNA4'>
        </speciesReference>
    </listOfProducts>
    <kineticLaw>
        <math xmlns='http://www.w3.org/1998/Math/MathML'>
           <apply><times/><apply><times/><ci>SOCS3RNADelay</ci><ci>SOCS3nRNA3</ci></apply><ci>nuc</ci></apply>
        </math>
    </kineticLaw>
</reaction>

<reaction id='reaction_31' reversible='false'>
    <listOfReactants>
        <speciesReference species='SOCS3nRNA4'>
        </speciesReference>
    </listOfReactants>
    <listOfProducts>
        <speciesReference species='SOCS3nRNA5'>
        </speciesReference>
    </listOfProducts>
    <kineticLaw>
        <math xmlns='http://www.w3.org/1998/Math/MathML'>
           <apply><times/><apply><times/><ci>SOCS3RNADelay</ci><ci>SOCS3nRNA4</ci></apply><ci>nuc</ci></apply>
        </math>
    </kineticLaw>
</reaction>

<reaction id='reaction_32' reversible='false'>
    <listOfReactants>
        <speciesReference species='SOCS3nRNA5'>
        </speciesReference>
    </listOfReactants>
    <listOfProducts>
        <speciesReference species='SOCS3RNA'>
        </speciesReference>
    </listOfProducts>
    <kineticLaw>
        <math xmlns='http://www.w3.org/1998/Math/MathML'>
           <apply><times/><apply><times/><ci>SOCS3RNADelay</ci><ci>SOCS3nRNA5</ci></apply><ci>nuc</ci></apply>
        </math>
    </kineticLaw>
</reaction>

<reaction id='reaction_33' reversible='false'>
    <listOfReactants>
        <speciesReference species='SOCS3RNA'>
        </speciesReference>
    </listOfReactants>
    <kineticLaw>
        <math xmlns='http://www.w3.org/1998/Math/MathML'>
           <apply><times/><apply><times/><ci>SOCS3RNATurn</ci><ci>SOCS3RNA</ci></apply><ci>cyt</ci></apply>
        </math>
    </kineticLaw>
</reaction>

<reaction id='reaction_34' reversible='false'>
    <listOfProducts>
        <speciesReference species='SOCS3'>
        </speciesReference>
    </listOfProducts>
    <listOfModifiers>
        <modifierSpeciesReference species='SOCS3RNA'>
        </modifierSpeciesReference>
    </listOfModifiers>
    <kineticLaw>
        <math xmlns='http://www.w3.org/1998/Math/MathML'>
           <apply><times/><apply><divide/><apply><times/><apply><times/><ci>SOCS3Eqc</ci><ci>SOCS3Turn</ci></apply><ci>SOCS3RNA</ci></apply><ci>SOCS3RNAEqc</ci></apply><ci>cyt</ci></apply>
        </math>
    </kineticLaw>
</reaction>

<reaction id='reaction_35' reversible='false'>
    <listOfReactants>
        <speciesReference species='SOCS3'>
        </speciesReference>
    </listOfReactants>
    <kineticLaw>
        <math xmlns='http://www.w3.org/1998/Math/MathML'>
           <apply><times/><apply><times/><ci>SOCS3Turn</ci><ci>SOCS3</ci></apply><ci>cyt</ci></apply>
        </math>
    </kineticLaw>
</reaction>

<reaction id='reaction_36' reversible='false'>
    <listOfProducts>
        <speciesReference species='SOCS3'>
        </speciesReference>
    </listOfProducts>
    <kineticLaw>
        <math xmlns='http://www.w3.org/1998/Math/MathML'>
           <apply><times/><apply><times/><apply><times/><ci>SOCS3oe</ci><ci>SOCS3Eqc</ci></apply><ci>SOCS3Turn</ci></apply><ci>SOCS3EqcOE</ci></apply>
        </math>
    </kineticLaw>
</reaction>

</listOfReactions>
</model>
</sbml>

Specie	Initial concentration
EpoRJAK2	3.97622 mmol
EpoRpJAK2	0 mmol
p1EpoRpJAK2	0 mmol
p2EpoRpJAK2	0 mmol
p12EpoRpJAK2	0 mmol
EpoRJAK2_CIS	0 mmol
SHP1	26.7251 mmol
SHP1Act	0 mmol
STAT5	79.7535 mmol
pSTAT5	0 mmol
npSTAT5	0 mmol
CISnRNA1	0 mmol
CISnRNA2	0 mmol
CISnRNA3	0 mmol
CISnRNA4	0 mmol
CISnRNA5	0 mmol
CISRNA	0 mmol
CIS	0 mmol
SOCS3nRNA1	0 mmol
SOCS3nRNA2	0 mmol
SOCS3nRNA3	0 mmol
SOCS3nRNA4	0 mmol
SOCS3nRNA5	0 mmol
SOCS3RNA	0 mmol
SOCS3	0 mmol
Epo	1.24997e-007 mmol

Reaction	Equation	Parameters
EpoRJAK2 EpoRpJAK2	$JAK2ActEpo Epo EpoRJAK2 SOCS3Inh SOCS3 SOCS3Eqc 1 cyt$	No information available
EpoRpJAK2 EpoRJAK2	$JAK2EpoRDeaSHP1 SHP1Act EpoRpJAK2 init_SHP1 cyt$	No information available
EpoRpJAK2 p1EpoRpJAK2	$EpoRActJAK2 EpoRpJAK2 SOCS3Inh SOCS3 SOCS3Eqc 1 cyt$	No information available
EpoRpJAK2 p2EpoRpJAK2	$3 EpoRActJAK2 EpoRpJAK2 SOCS3Inh SOCS3 SOCS3Eqc 1 EpoRCISInh EpoRJAK2_CIS 1 cyt$	No information available
p1EpoRpJAK2 p12EpoRpJAK2	$3 EpoRActJAK2 p1EpoRpJAK2 SOCS3Inh SOCS3 SOCS3Eqc 1 EpoRCISInh EpoRJAK2_CIS 1 cyt$	No information available
p2EpoRpJAK2 p12EpoRpJAK2	$EpoRActJAK2 p2EpoRpJAK2 SOCS3Inh SOCS3 SOCS3Eqc 1 cyt$	No information available
p1EpoRpJAK2 EpoRJAK2	$JAK2EpoRDeaSHP1 SHP1Act p1EpoRpJAK2 init_SHP1 cyt$	No information available
p2EpoRpJAK2 EpoRJAK2	$JAK2EpoRDeaSHP1 SHP1Act p2EpoRpJAK2 init_SHP1 cyt$	No information available
p12EpoRpJAK2 EpoRJAK2	$JAK2EpoRDeaSHP1 SHP1Act p12EpoRpJAK2 init_SHP1 cyt$	No information available
SHP1 SHP1Act	$SHP1ActEpoR SHP1 EpoRpJAK2 p12EpoRpJAK2 p1EpoRpJAK2 p2EpoRpJAK2 init_EpoRJAK2 cyt$	No information available
SHP1Act SHP1	$SHP1Dea SHP1Act cyt$	No information available
STAT5 pSTAT5	$STAT5ActJAK2 STAT5 EpoRpJAK2 p12EpoRpJAK2 p1EpoRpJAK2 p2EpoRpJAK2 init_EpoRJAK2 SOCS3Inh SOCS3 SOCS3Eqc 1 cyt$	No information available
STAT5 pSTAT5	$STAT5ActEpoR STAT5 p12EpoRpJAK2 p1EpoRpJAK2 2 init_EpoRJAK2 2 CISInh CIS CISEqc 1 SOCS3Inh SOCS3 SOCS3Eqc 1 cyt$	No information available
pSTAT5 npSTAT5	$STAT5Imp pSTAT5 cyt$	No information available
npSTAT5 STAT5	$STAT5Exp npSTAT5 nuc$	No information available
CISnRNA1 CISnRNA2	$CISRNADelay CISnRNA1 nuc$	No information available
CISnRNA2 CISnRNA3	$CISRNADelay CISnRNA2 nuc$	No information available
CISnRNA3 CISnRNA4	$CISRNADelay CISnRNA3 nuc$	No information available
CISnRNA4 CISnRNA5	$CISRNADelay CISnRNA4 nuc$	No information available
CISnRNA5 CISRNA	$CISRNADelay CISnRNA5 nuc$	No information available
SOCS3nRNA1 SOCS3nRNA2	$SOCS3RNADelay SOCS3nRNA1 nuc$	No information available
SOCS3nRNA2 SOCS3nRNA3	$SOCS3RNADelay SOCS3nRNA2 nuc$	No information available
SOCS3nRNA3 SOCS3nRNA4	$SOCS3RNADelay SOCS3nRNA3 nuc$	No information available
SOCS3nRNA4 SOCS3nRNA5	$SOCS3RNADelay SOCS3nRNA4 nuc$	No information available
SOCS3nRNA5 SOCS3RNA	$SOCS3RNADelay SOCS3nRNA5 nuc$	No information available

Simulate

Notes

not specified

Software

http://www.matlab.com (MATLAB)

BioModels or JWS Online ID

—

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Submission and curation

Entered by: Administrator KiMoSysFirst name: Administrator
Affiliation: INESC-ID/IST
Homepage: http://kdbio.inesc-id.pt/kimosys
Interests: mathematical modeling, accessible data, use of data

Created: 2014-04-23 17:30:03 UTC

Updated: 2014-06-30 17:59:26 UTC

Version: 0

Status: (reviewed) 2018-07-14 21:23:00 UTC

Views: 190

Downloads: 67

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APA	KiMoSys (https://kimosys.org). (2014, November 3). Model EntryID 31 (Mus musculus). https://kimosys.org/repository/81/associated_models/31
MLA	KiMoSys (https://kimosys.org). "Model EntryID 31 (Mus musculus)." 2025, kimosys.org/repository/81/associated_models/31.
ISO-690	KiMoSys (https://kimosys.org). Model EntryID 31 (Mus musculus). [online], [Accessed 3 November 2025]. Available from: https://kimosys.org/repository/81/associated_models/31
BibTeX	@misc{ KiMoSysModelEntryID31, author = "{KiMoSys (https://kimosys.org)}", title = "Model EntryID 31 (Mus musculus)", url = "https://kimosys.org/repository/81/associated_models/31", note = "[Online; accessed 3-November-2025]" }